Author

Heather M. Hager

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Eric Weh· 3 shared Thomas J. WubbeniD· 3 shared Andrew J. H. SmithiD· 2 shared Cagri G. BesirliiD· 2 shared Costas Andreas LyssiotisiD· 2 shared Mercy D. Pawar· 2 shared Peter SajjakulnukitiD· 2 shared Avi Weingarten· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersNeuroscience

Eric Weh

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Author profile →

3 papers

Recent·Most cited

Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress

Meini Chen, Eric Weh, Moloy T. Goswami, Katherine M. Weh, Heather M. Hager, Peter Sajjakulnukit, Avi Weingarten, Shubha Subramanya, Nicholas Miller, Sraboni Chaudhury, Emma Piraino, Navdeep S. Chandel, Renee C. Ryals, Costas Andreas Lyssiotis, Thomas J. Wubben

This study shows that GOT1 and GOT2 have opposing roles in rod photoreceptor health, with GOT2 acting as a neuroprotective factor under reductive stress conditions.

Redox Biology · Jun 18, 2026Peer-reviewedNeuroscience

Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress

Eric Weh, Zuzanna Lutrzykowska, Andrew J. H. Smith, Heather M. Hager, Mercy D. Pawar, Thomas J. Wubben, Cagri G. Besirli

This study shows that HK2 is not needed for photoreceptor development but is essential for their survival during aging and stress, with its non-enzymatic role in AKT signaling being critical.

Cell Death and Disease · Jun 4, 2020Peer-reviewedNeuroscience

Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, provides photoreceptor neuroprotection

Thomas J. Wubben, Mercy D. Pawar, Eric Weh, Andrew J. H. Smith, Peter Sajjakulnukit, Li Zhang, Lipeng Dai, Heather M. Hager, Manjunath P. Pai, Costas Andreas Lyssiotis, Cagri G. Besirli

This study shows that activating PKM2 with ML-265 protects photoreceptors from stress-induced apoptosis in vitro and in vivo.

Scientific Reports · Feb 19, 2020Peer-reviewedMolecular Biology