Anthony Bosco

WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm

This study shows that WNT signaling in hPSCs promotes mesoderm development through HDAC2-dependent epigenetic programs and RA responsiveness, enhancing T cell generation.

Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiation.

The paper identifies distinct plasma cell differentiation routes in humans using single-cell multiomic profiling and functional validation, showing CD30+ intermediates and their regulation by MEF2C and BAFF/APRIL.

Early, adjuvant-responsive epigenetic programs in B cells imprint subsequent plasma cell survival and the duration of humoral immunity

The paper identifies early epigenetic programs in B cells that influence plasma cell survival and humoral immunity duration, showing that ZBTB20 deficiency affects antibody responses when disrupted early post-immunization.

Decipher: A computational pipeline to extract context-specific mechanistic insights from single-cell profiles

Decipher identifies context-specific mechanistic insights from single-cell data by building cell signalling networks and uncovering disease-related pathways.