Tyler J. Ripperger

The paper identifies early epigenetic programs in B cells that influence plasma cell survival and humoral immunity duration, showing that ZBTB20 deficiency affects antibody responses when disrupted early post-immunization.

This study compares the replication ability of avian and mammalian-derived clade 2.3.4.4b H5N1 viruses in epithelial cells from different species, finding that mammalian strains replicate more broadly.

The paper shows that pre-existing immunity from H1N1 infection or vaccination can protect against lethal HPAI H5N1 clade 2.3.4.4b challenge in mice and ferrets, independent of hemagglutination inhibition titers.