Deepta Bhattacharya

This study shows that WNT signaling in hPSCs promotes mesoderm development through HDAC2-dependent epigenetic programs and RA responsiveness, enhancing T cell generation.

This study generates functional B cells from human pluripotent stem cells, recapitulating B lymphopoiesis stages and enabling plasma cell differentiation for therapeutic applications.

The paper identifies distinct plasma cell differentiation routes in humans using single-cell multiomic profiling and functional validation, showing CD30+ intermediates and their regulation by MEF2C and BAFF/APRIL.

A CRISPR screen identifies V-type ATPases, PI4K, DDX3X, and MYD88 as key regulators of secretory capacity and lifespan in long-lived plasma cells.

The paper identifies early epigenetic programs in B cells that influence plasma cell survival and humoral immunity duration, showing that ZBTB20 deficiency affects antibody responses when disrupted early post-immunization.

The paper shows that hematopoietic progenitors adjust to metabolic perturbations intrinsically to maintain homeostasis, independent of feedback from mature cells.