Author

Lucas J. D’Souza

University of ArizonaORCID 0000-0003-4132-7328Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Deepta BhattacharyaiD· 2 shared Anthony BoscoiD· 1 shared Darren A. CusanovichiD· 1 shared Edward P. Petrow· 1 shared Heather Coffman· 1 shared James F. ReadiD· 1 shared Jonathan N Young· 1 shared Lynn M. CorcoraniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Deepta BhattacharyaORCID

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2 papers

Recent·Most cited

ImmunologyThe Journal of ImmunologyPeer-reviewedFeb 1, 2026

A genome wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity

Lucas J. D’Souza, Jonathan N Young, Heather Coffman…·Deepta Bhattacharya

A CRISPR screen identifies V-type ATPases, PI4K, DDX3X, and MYD88 as key regulators of secretory capacity and lifespan in long-lived plasma cells.

2 citations

𝕏 PostBluesky

ImmunologybioRxivPreprintAug 15, 2025

Early, adjuvant-responsive epigenetic programs in B cells imprint subsequent plasma cell survival and the duration of humoral immunity

Tyler J. Ripperger, Lucas J. D’Souza, James F. Read…·Deepta Bhattacharya

The paper identifies early epigenetic programs in B cells that influence plasma cell survival and humoral immunity duration, showing that ZBTB20 deficiency affects antibody responses when disrupted early post-immunization.

DOI 10.1101/2025.08.15.666880

𝕏 PostBluesky