Jianyang Du

Functional specialization of mPFC-BLA and mPFC-NAc pathways in affective state representation

The paper identifies distinct functional roles of mPFC-BLA and mPFC-NAc pathways in representing anxiety-like and positive valenced behavioral states through neural activity patterns.

Divergent Neurobehavioral Effects of CFTR Modulators Elexacaftor and Ivacaftor in Mice

This study examines the neurobehavioral effects of CFTR modulators elexacaftor and ivacaftor in mice, finding anxiety-like and depressive-like behaviors respectively.

TRPC3 suppression ameliorates synaptic dysfunctions and memory deficits in Alzheimer's disease

This study identifies TRPC3 as a therapeutic target for Alzheimer's disease by showing its role in synaptic dysfunction and memory deficits, with JW-65 as a potential inhibitor.

Acid-sensing ion channel 1a contributes to the prefrontal cortex ischemia-enhanced neuronal activities in the amygdala

This study investigates the role of ASIC1a in post-stroke neural circuit reconfiguration, showing its involvement in enhanced synaptic plasticity and amygdala activity following prefrontal cortex ischemia.

SARS-CoV-2 neurotropism-induced anxiety and depression-like behaviors require Microglia activation

This study shows that SARS-CoV-2 infection leads to microglia activation and behavioral changes, suggesting microglia as a target for treating virus-induced neurobehavioral issues.

Neuronal acid-sensing ion channel 1a regulates neuron-to-glioma synapses

This study identifies the neuronal H+-Asic1a axis as a regulator of neuron-glioma synapses, showing reduced tumor growth in Asic1a-deficient mice.

Proton receptors regulate synapse-specific reconsolidation in the amygdala

This study shows that CO2 inhalation during memory retrieval increases aversive memory lability through synapse-specific reconsolidation via proton receptors.