Xusheng Wang

APOE is a presynaptic protein that accumulates with age and modulates neurotransmitter release

This study identifies APOE as a presynaptic protein enriched in aged female mice, showing it modulates neurotransmitter release and affects synaptic function.

The impact of common variants on gene expression in the human brain: from RNA to protein to schizophrenia risk

The paper identifies eQTLs, rQTLs, and pQTLs in the human brain and shows that many eQTL effects are attenuated post-transcriptionally, yet still correlate with schizophrenia GWAS signals.

Precision and Accuracy in Quantitative Measurement of Gene Expression from Single-Cell/Nuclei RNA Sequencing Data

This study evaluates precision and accuracy in sc/snRNA-seq data, identifies factors affecting reproducibility, and introduces a tool to assess data quality and differential expression reliability.

SLFN11 Loss-Induced Chemoresistance is Associated with Overexpression of Glycerophospholipid Biosynthesis in Ewing Sarcoma.

The paper identifies glycerophospholipid biosynthesis upregulation as a mechanism of chemoresistance in SLFN11-loss Ewing sarcoma and shows that inhibiting this pathway enhances DNA-damaging agent efficacy.

Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation

This study shows that midkine reduces Aβ fibril formation and amyloid plaque development in Alzheimer's disease models.

Genetic Modulation of Protein Expression in Rat Brain

This study quantifies protein expression in rat brains, identifies pQTLs, and links them to behavioral traits and human disorders.

Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

TRPC3 suppression ameliorates synaptic dysfunctions and memory deficits in Alzheimer's disease

This study identifies TRPC3 as a therapeutic target for Alzheimer's disease by showing its role in synaptic dysfunction and memory deficits, with JW-65 as a potential inhibitor.

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms

The paper identifies extensive isoform diversity in the developing human neocortex and links it to neuropsychiatric disorder risk mechanisms.

Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data

The paper evaluates deconvolution methods on human brain data, finding dtangle and bMIND perform best, and identifies decon-eQTLs that explain more schizophrenia heritability than bulk or single-cell eQTLs.

Multimodal joint deconvolution and integrative signature selection in proteomics

The paper introduces a method for deconvolving bulk proteomes using transcriptome-proteome integration and applies it to identify cell-type-specific protein quantitative trait loci.

A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats

The paper presents an improved rat reference genome, mRatBN7.2, which enhances genomic, transcriptomic, and proteomics data mapping and identifies millions of genetic variations across rat strains.

Human brain aging heterogeneity observed from multi-region omics data reveals a subtype closely related to Alzheimer's disease

The paper identifies an AD-like subtype in brain aging across multiple regions, showing overlap with AD gene signatures and regional differences in gene expression.

Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids

This study shows that ATM-mediated phosphorylation of 53BP1-serine 25 is essential for neural progenitor cell proliferation and neuronal differentiation in cortical organoids.

SMAP: A pipeline for sample matching in proteogenomics

SMAP is a pipeline that matches proteomic and genomic samples using protein-coding variants and discriminant scores, correcting 18.8% of mismatches in a large-scale proteomics dataset.

Identification of a functional non-coding variant in the GABAA receptor α2 subunit of the C57BL/6J mouse reference genome: Major implications for neuroscience research

The paper identifies a functional non-coding variant in the GABRA2 gene of the C57BL/6J mouse strain, showing its impact on Gabra2 expression and implications for neuroscience research.