Author

Robert T. O’Neill

Scripps Research InstituteORCID 0000-0002-4348-7635Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:cryo-EM· 1 Assay:electronic health records· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Evan T. PowersiD· 2 shared Jeffery W. KellyiD· 2 shared Danielle Ann GrotjahniD· 1 shared Gabriel C. LanderiD· 1 shared Jan-Hannes Schaefer· 1 shared Jan-Hannes SchäferiD· 1 shared Joseph P. DonnellyiD· 1 shared Zi GaoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

Evan T. PowersORCID

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2 papers

Recent·Most cited

Tailocins are recurrent contaminants in ex vivo amyloid extraction

Jan-Hannes Schäfer, Robert T. O’Neill, Zi Gao, Danielle Ann Grotjahn, Evan T. Powers, Jeffery W. Kelly

The paper identifies tailocins as contaminants in ex vivo amyloid preparations and proposes strategies to detect and avoid them in cryo-EM.

bioRxiv · Sep 14, 2026 · PreprintBiophysics

Helical Reconstruction of Amyloids in cryoSPARC

Jan-Hannes Schaefer, Robert T. O’Neill, Joseph P. Donnelly, Evan T. Powers, Jeffery W. Kelly, Gabriel C. Lander

This paper provides processing guidelines for helical reconstruction of amyloids using cryoSPARC, highlighting current capabilities and limitations while advocating for amyloid-specific parameter optimization.

Acta Crystallographica Section F Structural Biology Communications · May 5, 2026Peer-reviewedBioinformatics