Zi Gao

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

The paper introduces rank normalization to compare protein turnover across degradation pathways, revealing pathway-specific substrate preferences and proteaphagy.

The paper identifies tailocins as contaminants in ex vivo amyloid preparations and proposes strategies to detect and avoid them in cryo-EM.

This study uses proteomics and 3D imaging to show that ATTR cardiac amyloidosis involves microangiopathy, capillary occlusion, and vascular basement membrane congestion.

The paper develops a HaloTag-4R-Tau sensor to study tau clearance in iNeurons and identifies Neddylation inhibition as a method to promote tau degradation.

This study uses human iPSC-derived cortical organoids to model familial Alzheimer's disease and shows that autophagy activators reduce pathological Tau and Aβ accumulation and rescue synaptic loss.