Author

Joseph P. Donnelly

Scripps Research InstituteORCID 0000-0002-8254-433XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:proteomics· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Evan T. PowersiD· 2 shared Gabriel C. LanderiD· 2 shared Jeffery W. KellyiD· 2 shared Carl T. AshiD· 1 shared Jan-Hannes Schaefer· 1 shared Jan-Hannes SchäferiD· 1 shared Karina NugrohoiD· 1 shared Leonard YooniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBioinformatics

Evan T. PowersORCID

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2 papers

Recent·Most cited

Helical Reconstruction of Amyloids in cryoSPARC

Jan-Hannes Schaefer, Robert T. O’Neill, Joseph P. Donnelly, Evan T. Powers, Jeffery W. Kelly, Gabriel C. Lander

This paper provides processing guidelines for helical reconstruction of amyloids using cryoSPARC, highlighting current capabilities and limitations while advocating for amyloid-specific parameter optimization.

Acta Crystallographica Section F Structural Biology Communications · May 5, 2026Peer-reviewedBioinformatics

3D Visualization and Proteomic Analysis of Human Cardiac Transthyretin Amyloidosis Tissue Reveals Microangiopathy and Capillary Occlusion

Joseph P. Donnelly, Jan-Hannes Schäfer, Leonard Yoon, Lynée A. Massey, Carl T. Ash, Zi Gao, Karina Nugroho, Marcus Jäger, Zhengyuan Pang, Robert T. O'Neill, Mathew S. Maurer, Evan T. Powers, Gabriel C. Lander, Ye Li, Jeffery W. Kelly

This study uses proteomics and 3D imaging to show that ATTR cardiac amyloidosis involves microangiopathy, capillary occlusion, and vascular basement membrane congestion.

bioRxiv · Feb 11, 2026 · PreprintPathology