Author

Manuel de Lera Ruiz

Merck & Co., Inc., Rahway, NJ, USA (United States)ORCID 0000-0002-4355-9782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:plant (other)· 1

Frequent Co-Authors

Alan F. CowmaniD· 1 shared Anna NgoiD· 1 shared Anthony N. HodderiD· 1 shared Anthony T. PapenfussiD· 1 shared Brad E. SleebsiD· 1 shared Danushka S. MarapanaiD· 1 shared David B. OlseniD· 1 shared Jennifer K. Thompson· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Alan F. CowmanORCID

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1 paper

Recent·Most cited

Dual plasmepsin IX and X inhibitors are refractory to development of resistance

Paola Favuzza, Madeline G. Dans, Wenyin Su, Jennifer K. Thompson, Anthony N. Hodder, Anna Ngo, Jocelyn Sietsma Penington, Danushka S. Marapana, Jerzy Michal Dziekan, Anthony T. Papenfuss, Manuel de Lera Ruiz, Rachael Coyle, Marcus C. S. Lee, John A. McCauley, Kym N. Lowes, , Alan F. Cowman

This study evaluates resistance development to PMX-selective and dual PMIX/X inhibitors in Plasmodium falciparum, finding that dual inhibitors have a higher resistance barrier.

PLoS Pathogens · Sep 8, 2026Peer-reviewedMicrobiology