Author

Marcus C. S. Lee

University of Dundee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Organism:plant (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

Rachael CoyleiD· 2 shared Alan F. CowmaniD· 1 shared Anna NgoiD· 1 shared Anthony N. HodderiD· 1 shared Anthony T. PapenfussiD· 1 shared Arne AlderiD· 1 shared Brad E. SleebsiD· 1 shared Charisse Flerida A. PasajeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Rachael CoyleORCID

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2 papers

Recent·Most cited

Dual plasmepsin IX and X inhibitors are refractory to development of resistance

Paola Favuzza, Madeline G. Dans, Wenyin Su, Jennifer K. Thompson, Anthony N. Hodder, Anna Ngo, Jocelyn Sietsma Penington, Danushka S. Marapana, Jerzy Michal Dziekan, Anthony T. Papenfuss, Manuel de Lera Ruiz, Rachael Coyle, Marcus C. S. Lee, John A. McCauley, Kym N. Lowes, , Alan F. Cowman

This study evaluates resistance development to PMX-selective and dual PMIX/X inhibitors in Plasmodium falciparum, finding that dual inhibitors have a higher resistance barrier.

PLoS Pathogens · Sep 8, 2026Peer-reviewedMicrobiology

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation

Kathryn J. Wicht, John G. Woodland, Larnelle F. Garnie, Henrico Langeveld, Dale Taylor, Luiz Claudio Godoy, Charisse Flerida A. Pasaje, Mariana Laureano de Souza, Jair L. Siqueira-Neto, Sonja Ghidelli, María José Lafuente-Monasterio, Francisco‐Javier Gamo, Dina Coertzen, Janette Reader, Mariëtte van der Watt, , Kelly Chibale

This study shows that CHIR-124, a human Chk1 inhibitor, is active against Plasmodium falciparum through dual inhibition of PfArk1 and hemozoin formation, suggesting polypharmacology as a strategy for antimalarial drugs.

ACS Chemical Biology · Jun 13, 2026Peer-reviewedMicrobiology