Christopher R. S. Banerji

Normal Breast Tissue (NBT)-Classifiers: Advancing Compartment Classification in Normal Breast Histology

CNN patch classifiers trained only on normal breast H&E slides label epithelium, stroma and adipocytes with AUCs of 0.98–1.00 on three external cohorts and feed a lobule-detection pipeline.

Mitochondrial Respiratory Chain Function is crucial for Muscle Toxicity in Facioscapulohumeral Muscular Dystrophy

This study identifies mitochondrial respiratory chain dysfunction and reverse electron transfer as key drivers of DUX4-induced toxicity in FSHD, suggesting RET inhibition as a therapeutic target.

CEBPβ regulates myoblast proliferation and myogenic differentiation during human myogenesis and rescues defective differentiation in FSHD

This study shows CEBPβ regulates human myoblast proliferation and differentiation, and its altered expression contributes to defective myogenesis in FSHD.

Quantifying anti-DUX4 therapy for facioscapulohumeral muscular dystrophy

This paper develops a mathematical model to evaluate anti-DUX4 therapies for FSHD, finding that reducing DUX4 diffusion is more effective than reducing apoptosis, and that combining strategies yields better results.

Charting cellular differentiation trajectories with Ricci flow

This paper applies Ricci flow to model network rewiring during cellular differentiation using single-cell RNA-seq data, showing that network entropy and Ricci curvature provide complementary insights.

A circulating biomarker of facioscapulohumeral muscular dystrophy clinical severity, valid in skeletal muscle and blood

The paper identifies a circulating transcriptomic biomarker in blood that correlates with FSHD clinical severity and validates it in muscle tissue.

Lymphocytes contribute to DUX4 target genes in FSHD muscle biopsies

The paper shows that DUX4 and its target genes are expressed in immune cells, not muscle cells, in FSHD muscle biopsies, correlating with inflammation.