Johannes Grillari

This study identifies acetylation-dependent remodeling of the secretory pathway in senescence, showing its role in shaping the senescence-associated secretome.

The paper identifies surface-bound RNA on extracellular vesicles and shows it is co-delivered to target cells, suggesting a new RNA uptake mechanism.

This study identifies mitochondrial respiratory chain dysfunction and reverse electron transfer as key drivers of DUX4-induced toxicity in FSHD, suggesting RET inhibition as a therapeutic target.

This paper introduces a Snorkel-tag system for affinity purification of extracellular vesicles using CD81 fused with tags and transmembrane domains, enabling non-destructive isolation and future applications in tracing and analyzing EVs.

The paper profiles miRNA expression during senescence and aging to identify potential circulating biomarkers of senescent cell burden in mice and humans.

This study establishes quartz crystal microbalance (QCM) as a label-free method to characterize extracellular vesicles and their surface proteins, enabling improved quality control of EV-based therapeutics.

This study compares extracellular miRNA profiles in lipedema and healthy adipose tissue, finding that sEV miRNAs are differentially regulated in lipedema.

The paper identifies altered 2-O-methylation patterns in rRNA associated with senescence and quiescence in human fibroblasts using RiboMeth-seq.

This study identifies miR-146a as a key regulator of age-related bone loss, showing its role in controlling bone homeostasis through Wnt signaling and its potential as a therapeutic target.

This study examines miRNA changes in bone and blood during bisphosphonate and teriparatide treatment in an osteoporosis animal model, finding significant miRNA regulation linked to bone remodeling.