Author

Yichi Niu

Baylor College of MedicineORCID 0000-0002-4376-7792Unclaimed ORCID profile · follow to get notified of new preprints

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Yichi Niu2 papers

Biology Disciplines

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Genomics· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:long-read sequencing· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Chenghang Chuck ZongiD· 3 shared Chuan HeiD· 1 shared Jiayi LuoiD· 1 shared Kinga PajdzikiD· 1 shared Kuanwei ShengiD· 1 shared Michael C. GundryiD· 1 shared Ming Hao· 1 shared Muchun NiuiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersGenomics

Chenghang Chuck ZongORCID

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3 papers

Recent·Most cited

Single-nucleotide Resolution Epitranscriptomic Profiling Uncovers Dynamic m6A Regulation in Bovine Preimplantation Development

Rajan Iyyappan, Yichi Niu, Ming Hao, Kinga Pajdzik, Noah R. Rakestraw, Piyush Jain, Chuan He, Chenghang Chuck Zong, Zongliang Jiang

This study uses SAC-seq to map m6A modifications at single-nucleotide resolution in bovine preimplantation embryos, identifying a critical m6A site in RPL12 that regulates translation and development.

bioRxiv · Jul 7, 2025 · PreprintDevelopmental Biology

Single-cell Total-RNA Profiling Unveils Regulatory Hubs of Transcription Factors

Yichi Niu, Jiayi Luo, Chenghang Chuck Zong

The paper introduces snapTotal-seq, a single-cell RNA-seq method that measures both nascent and mature RNA, and identifies regulatory hubs in cell cycle and senescence using LASSO regression.

Nature Communications · Jul 15, 2024Peer-reviewedGenomics

Topologically Dependent Abundance of Spontaneous DNA Damage in Single Human Cells

Qiangyuan Zhu, Yichi Niu, Michael C. Gundry, Kuanwei Sheng, Muchun Niu, Chenghang Chuck Zong

This paper introduces a new single-cell WGA method to detect DNA damage-associated variants and finds that dSNV abundance is linked to genome topological compartments.

bioRxiv · Dec 23, 2019 · PreprintGenomics