Zena K. Chatila

This study shows how non-coding variants in CD33 affect Alzheimer's risk by altering CD33M dimerization and interactions with clusterin and Aβ, impacting microglial function.

The paper investigates how AD risk variants in CD33 and SPI1 affect monocyte function in response to amyloid-beta, showing reduced phagocytosis and TREM2 loss.

This study identifies CD45 as a sialic acid-dependent binding partner of CD33, showing that their interaction contributes to Alzheimer's disease susceptibility through impaired microglial function.

This paper investigates the role of alpha-synuclein in lipid regulation at MAM domains in synucleinopathies, showing disease-specific lipid alterations and Syn's impact on phosphatidylserine metabolism.

The paper uses single-nucleus RNA- and ATAC-sequencing to identify a CD83+ microglial subpopulation depleted in Parkinson's disease, with implications for neuronal vulnerability.