Author
Columbia UniversityORCID 0000-0002-7283-3883Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Matthew James Jennings, Audrey Anigbo, Serge Przedborski
The paper develops a combined gait and pose analysis method using CatWalk XT videos to detect motor phenotypes in mice with synucleinopathy.
bioRxiv · Mar 11, 2026 · PreprintNeuroscience
Irene Faravelli, Paola Rinchetti, Monica Tambalo, Illia Simutin, Lisa Mapelli, Sara Mancinelli, Matteo Miotto, Mafalda Rizzuti, Andrea D’Angelo, Chiara Cordiglieri, Giulia Forotti, Clelia Peano, Paolo Kunderfranco, Luca Calandriello, Giacomo P. Comi, , Stefania Paola Corti
This study shows that early ASO treatment rescues developmental defects in SMA organoids by restoring SMN levels and correcting splicing defects.
Nature Communications · Dec 21, 2025Peer-reviewedNeuroscience
Riccardo Curró, Natalia Dominik, Stefano Facchini, Ricardo Parolin Schnekenberg, Cecilia Perini, Riccardo Ronco, Bianca Rugginini, Arianna Ghia, Silvia Bione, Nadia Tagliaferri, Glenda Paola Grupelli, Simon A. Lowe, Amy R. Hicks, Elisa Vegezzi, Roberto Simone, , Andrea Cortese
bioRxiv · Nov 18, 2025 · PreprintNeuroscience
John F. Tuddenham, Masashi Fujita, Emily Lee, Nivedita Nimmagadda, Anthony Khairallah, Claire Harbison, Xena E. Flowers, Guillermo Coronas‐Samano, Silas Maniatis, Aidan C. Daly, Julie A. Schneider, Andrew F. Teich, Jean Paul Vonsattel, Peter A. Sims, Wassim Elyaman, , Marta Olah
The paper identifies microglia subsets in ALS brain and spinal cord, finding an undifferentiated phenotype and enrichment of interferon response microglia in aggressive cases.
Acta Neuropathologica · Jul 29, 2025Peer-reviewedNeuroscience
Peter A. Barbuti, Cristina Guardia‐Laguarta, Taekyung Yun, Zena K. Chatila, Xena E. Flowers, Chantel Wong, Bruno F. R. Santos, Simone B. Larsen, James S. Lotti, Nobutaka Hattori, Elizabeth M. Bradshaw, Ulf Dettmer, Saranna Fanning, Vilas Menon, Hasini Reddy, , Serge Przedborski
This paper investigates the role of alpha-synuclein in lipid regulation at MAM domains in synucleinopathies, showing disease-specific lipid alterations and Syn's impact on phosphatidylserine metabolism.
npj Parkinson s Disease · Apr 30, 2025Peer-reviewedNeuroscience
Alec J. Batts, Robin Ji, Sua Bae, Fotios N. Tsitsos, Sergio Jiménez-Gambín, Nancy Kwon, Samantha L. Gorman, Deny Tsakri, Rebecca Lynn Noel, Jonas Bendig, Daniella Amanda Jimenez, Melody R. DiBenedetto, Sofia A. Del Castillo, Filimon B. Keleta, James Caicedo, , Elisa E. Konofagou
Portable therapeutic ultrasound enhanced AAV9 delivery to the brain in mice and rhesus macaques compared to systemic injection alone.
bioRxiv · Mar 2, 2025 · PreprintBioengineering
Nancy Kwon, Alec J. Batts, Hairong Zhang, Vernice R. Jackson-Lewis, Elisa E. Konofagou, Serge Przedborski
This study evaluates the feasibility of using focused ultrasound to deliver an anti-alpha-synuclein antibody to Parkinson's disease mouse models, showing successful BBB opening and antibody delivery.
bioRxiv · Sep 13, 2024 · PreprintNeuroscience
Zena K. Chatila, A. Yadav, J. Mares, Xena E. Flowers, Taekyung Yun, M. Rashid, Ryan Talcoff, Z. Pelly, Ya Zhang, Philip L. De Jager, Andrew F. Teich, Rui M. Costa, Estela Área-Gómez, G. Martins, Roy N. Alcalay, , Serge Przedborski
The paper uses single-nucleus RNA- and ATAC-sequencing to identify a CD83+ microglial subpopulation depleted in Parkinson's disease, with implications for neuronal vulnerability.
bioRxiv · May 17, 2023 · PreprintNeuroscience