Isoflurane and surgery aggravate APOE4-dependent lipid dysregulation and neural dysfunction, leading to neurological impairment in male mice
Yun Li, Yuanyuan Ji, Çoşar Uzun, Syed Taufiqul Islam, Meigeng Hu, Dan Zhao, Yaping Li, Hangnoh Lee, Zihui Wang, Hui Li, Jace W. Jones, Shaolin Liu, Junfang Wu
This study shows that isoflurane anesthesia and surgery worsen lipid dysregulation and neural dysfunction in APOE4 mice, leading to neurological impairments.
bioRxiv · Aug 5, 2026 · PreprintNeuroscience