Junfang Wu

This study shows that isoflurane anesthesia and surgery cause chronic sex-dependent neurological issues in mice, linked to changes in brain transcriptomes and circulating extracellular vesicles.

This study shows that Hv1 deficiency in mice leads to increased mortality and immune dysfunction after TBI, with significant effects on splenic antibacterial defense and immune homeostasis.

This study shows that isoflurane anesthesia and surgery worsen lipid dysregulation and neural dysfunction in APOE4 mice, leading to neurological impairments.

This study identifies cGAS-mediated IFN-I signaling as a driver of disease progression in drug-refractory epilepsy, showing that targeting cGAS reduces epileptic phenotypes and inflammation.

This study shows that brain injury accelerates age-related microglial changes linked to hyperphagocytosis and neurodegeneration in old mice.

This study shows that removing microglia with a CSF1R inhibitor after TBI reduces neurodegeneration and improves neurological outcomes.