Saaya Enomoto

Novel Biomaterial-Based Synovial Fluid Analysis Reveals Protective microRNA Signatures in a Mouse Model of Acute Synovitis-Driven Osteoarthritis

This study uses a mouse model to investigate how acute synovitis and mechanical stress contribute to PTOA, identifying miRNA signatures in synovial fluid that may protect against cartilage degeneration.

A Novel Slow-Progressive Knee Osteoarthritis Murine Model Induced by Non-Invasive Posterior Cruciate Ligament Rupture in Mice

This study develops a murine model of slow-progressing knee osteoarthritis by inducing non-invasive posterior cruciate ligament rupture and compares its progression to the destabilized medial meniscus model.

Concurrent Joint Contact in Anterior Cruciate Ligament Injury induces cartilage micro-injury and subchondral bone sclerosis, resulting in knee osteoarthritis

This study compares the effects of cartilage compression and joint instability on post-traumatic osteoarthritis progression after ACL injury in mice.

Strict Early Knee Stabilization Favors Spontaneous Anterior Cruciate Ligament Healing: Implications for Non-Operative Management from a Murine Rupture Model

This study shows that strict early knee stabilization improves ACL healing in mice, while mild restraint reduces healing rates and tissue quality.

Joint Instability Causes Catabolic Enzyme Production in Chondrocytes prior to Synovial Cells in Novel Non-Invasive ACL ruptured Mouse Model

This study establishes a non-invasive ACL-ruptured mouse model to investigate OA progression, finding that chondrocytes respond to mechanical stress before synovial cells.