Yuna Usami

A Novel Slow-Progressive Knee Osteoarthritis Murine Model Induced by Non-Invasive Posterior Cruciate Ligament Rupture in Mice

This study develops a murine model of slow-progressing knee osteoarthritis by inducing non-invasive posterior cruciate ligament rupture and compares its progression to the destabilized medial meniscus model.

Mechanical Force Works as a Biological Cue in Postnatal Murine Tendon Development

This study examines mechanical forces during murine tendon development, finding that increased movement correlates with upregulation of Scx and Tnmd.

Muscle Contraction is Essential for Tendon Healing and Muscle Function Recovery after Achilles Tendon Rupture and Surgical Repair

This study shows that electrical muscle stimulation improves tendon healing and muscle recovery after Achilles tendon rupture, while static stretching has no additional benefit.

Strict Early Knee Stabilization Favors Spontaneous Anterior Cruciate Ligament Healing: Implications for Non-Operative Management from a Murine Rupture Model

This study shows that strict early knee stabilization improves ACL healing in mice, while mild restraint reduces healing rates and tissue quality.

Joint Instability Causes Catabolic Enzyme Production in Chondrocytes prior to Synovial Cells in Novel Non-Invasive ACL ruptured Mouse Model

This study establishes a non-invasive ACL-ruptured mouse model to investigate OA progression, finding that chondrocytes respond to mechanical stress before synovial cells.