A Novel Slow-Progressive Knee Osteoarthritis Murine Model Induced by Non-Invasive Posterior Cruciate Ligament Rupture in Mice
Saaya Enomoto, Kohei Arakawa, Kei Takahata, Michiaki Sato, Himari Miyamoto, Riku Saito, Yuna Usami, Koyo Nogi, Takanori Kokubun
This study develops a murine model of slow-progressing knee osteoarthritis by inducing non-invasive posterior cruciate ligament rupture and compares its progression to the destabilized medial meniscus model.
bioRxiv · May 14, 2026 · PreprintPathology