Takanori Kokubun

This study uses a mouse model to investigate how acute synovitis and mechanical stress contribute to PTOA, identifying miRNA signatures in synovial fluid that may protect against cartilage degeneration.

This study develops a murine model of slow-progressing knee osteoarthritis by inducing non-invasive posterior cruciate ligament rupture and compares its progression to the destabilized medial meniscus model.

This study compares the effects of cartilage compression and joint instability on post-traumatic osteoarthritis progression after ACL injury in mice.

This study examines mechanical forces during murine tendon development, finding that increased movement correlates with upregulation of Scx and Tnmd.

This study shows that electrical muscle stimulation improves tendon healing and muscle recovery after Achilles tendon rupture, while static stretching has no additional benefit.

This study shows that strict early knee stabilization improves ACL healing in mice, while mild restraint reduces healing rates and tissue quality.

This study establishes a non-invasive ACL-ruptured mouse model to investigate OA progression, finding that chondrocytes respond to mechanical stress before synovial cells.