Molecular BiologyOncogenesisPeer-reviewed
Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.
Sandeep Kumar, Xiangdong Peng, James M. Daley…·Guang Peng
This study identifies DNA2 nuclease as a therapeutic target for cancer by showing its overexpression in pancreatic cancer and its role in HR repair, with inhibitors reducing tumor growth and HR repair.
66 citations