Hengyao Niu

This study quantifies information-processing-like properties of human cortical organoids using a functional phenotyping framework, linking network function to disease-related mutations and pharmacological perturbations.

This study shows PARP1 prevents TOP1 from causing deletions at STRs by inhibiting TOP1-DNA adduct formation, which could inform therapies for cancers with RNase H2 mutations.

This study shows that Cdc13's dual DNA-binding capability coordinates with Ku to protect telomeres, and mutations in this function lead to metabolic reprogramming and increased fitness in yeast.

This study shows that DNA polymerase δ proofreading nuclease inhibits translesion synthesis and promotes recombination during DNA lesion bypass.

This study shows that Cdc13 can dynamically exchange DNA strands in the presence of telomeric DNA, revealing a mechanism for its movement at telomeres.

This study identifies DNA2 nuclease as a therapeutic target for cancer by showing its overexpression in pancreatic cancer and its role in HR repair, with inhibitors reducing tumor growth and HR repair.