Sandeep Kumar

The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging

The paper shows captopril extends lifespan in worms and mice by inhibiting ACN-1, which regulates dauer formation and interacts with daf genes.

A dual MTOR/NAD+ acting gerotherapy

This paper identifies BIOIO-1001 as a dual mTOR/NAD+ acting gerotherapy that reduces metabolic derangements, inflammation, and fibrosis in NASH and ALS models.

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.

The paper identifies ATRAID as a gene critical for the response to nitrogen-containing bisphosphonates, showing its role in drug efficacy and resistance in osteoporosis.

Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens

This study identifies that multiple cationic amphipathic drugs (CADs) share molecular similarities with chloroquine and inhibit sphingolipid biosynthesis, suggesting their potential as antiviral agents against diverse pathogens including SARS-CoV-2.

Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.

This study identifies DNA2 nuclease as a therapeutic target for cancer by showing its overexpression in pancreatic cancer and its role in HR repair, with inhibitors reducing tumor growth and HR repair.