Author

James M. Daley

The University of Texas at San Antonio Health Science CenterORCID 0000-0002-7706-6134Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Patrick SungiD· 2 shared Alexander V. MaziniD· 1 shared Angela M. JasperiD· 1 shared Antoine BaudiniD· 1 shared C Rao· 1 shared CLIFFORD C. STEPHANiD· 1 shared Cody M. RogersiD· 1 shared David S. LibichiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Patrick SungORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 30, 2026

BRCA1 promotes homologous recombination through separable DNA and RAD51 binding activities within its disordered region.

Angela M. Jasper, Hoang H. Dinh, Wenjing Li…·David S. Libich

This study identifies DNA binding and RAD51 interaction interfaces in BRCA1's disordered region and shows their distinct roles in homologous recombination and DNA repair.

1 citation

experimental assaybiophysical modeling

𝕏 PostBluesky

Molecular BiologyOncogenesisPeer-reviewedApr 17, 2017

Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.

Sandeep Kumar, Xiangdong Peng, James M. Daley…·Guang Peng

This study identifies DNA2 nuclease as a therapeutic target for cancer by showing its overexpression in pancreatic cancer and its role in HR repair, with inhibitors reducing tumor growth and HR repair.

66 citations

humanexperimental assay

𝕏 PostBluesky