Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.
Sandeep Kumar, Xiangdong Peng, James M. Daley, Lin Yang, Jianfeng Shen, Nghi Co Nguyen, G Bae, Hengyao Niu, Yang Peng, H-J Hsieh, Lili Wang, C Rao, CLIFFORD C. STEPHAN, Patrick Sung, G Ira, Guang Peng
This study identifies DNA2 nuclease as a therapeutic target for cancer by showing its overexpression in pancreatic cancer and its role in HR repair, with inhibitors reducing tumor growth and HR repair.
Oncogenesis · Apr 17, 2017Peer-reviewedMolecular Biology