Author

Derek G. Doherty

Trinity College DublinORCID 0000-0002-4394-658XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Bashir M. MohamediD· 3 shared Feras Abu SaadehiD· 3 shared Steven G. GrayiD· 3 shared Cara Martin· 2 shared Doug A. BrooksiD· 2 shared Elena MatsaiD· 2 shared John J. O`Leary· 2 shared Musha Yang· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Bashir M. MohamedORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Single-Cell Isolation and Patient-Derived Organoid Generation Using the Pala™ Single Cell Dispenser with Cancer Cell Lines Spiked into Blood as a Circulating Tumour Cell Model: A Platform for Precision Oncology and Drug Discovery

Shambhavi Krishna, Fatma Yaren Giray, Musha Yang, Karolina Stirblyte, Steven G. Gray, Feras Abu Saadeh, Marie Reidy, Cara Martin, Sharon A. O'Toole, Doug A. Brooks, Stavros Selemidis, Derek G. Doherty, Elena Matsa, John J. O`Leary, Steven Johnstone, Bashir M. Mohamed

This paper validates the Pala™ Single Cell Dispenser for isolating cancer cells and generating patient-derived organoids, showing higher efficiency and viability than FACS.

bioRxiv · Jun 16, 2026 · PreprintCancer Biology

Nanoparticle mediated delivery of PD-L1 inhibitor enhances γδ T cell immunotherapy against metastatic ovarian cancer cells

Laura O’conner, Jessica Eakins, Mark Bates, Ola Ibrahim, C Medina Martin, Victoria Malone, Steven G. Gray, Feras Abu Saadeh, Hassan Rajab, Doug A. Brooks, Ciarán Manus Maguire, Stavros Selemidis, Julie David, Elena Matsa, Sharon A. O’Toole, , Bashir M. Mohamed

This study shows that nanoparticle-delivered PD-L1 inhibitor enhances γδ T cell killing of platelet-cloaked ovarian cancer cells in vitro.

bioRxiv · Jun 9, 2026 · PreprintImmunology

Clove Aqueous Extract Triggers a Multi-Organellar Stress Crisis through Lysosomal Destabilisation and Mitochondrial Hyperpolarisation to Suppress Patient-Derived Ovarian Cancer Cells

Yazid K. Ghanem, Hadeel Odwan, Musha Yang, Victoria Malone, Fawza Alenazi, Feras Abu Saadeh, S. Gray, Derek G. Doherty, Cara Martin, Sharon A. O'Toole, John J. O`Leary, Bashir M. Mohamed

This study shows that clove aqueous extract induces multi-organellar stress in ovarian cancer cells by disrupting lysosomes and mitochondria, leading to cell death.

bioRxiv · Feb 2, 2026 · PreprintCancer Biology