Transfer RNA acetylation regulates in vivo mammalian stress signaling
Supuni Thalalla Gamage, Roxane Khoogar, Shereen A. Howpay Manage, Judey T. DaRos, McKenna C. Crawford, Joe Georgeson, Bogdan V. Polevoda, Chelsea Sanders, Kendall A. Lee, Kellie D. Nance, Vinithra Iyer, Anatoly Kustanovich, Minervo Perez, Chu T. Thu, Sam R. Nance, , Jordan L. Meier
This study shows that tRNA acetylation regulates stress signaling in mammals by affecting ribosome function and interacting with the Gcn2 kinase.
Science Advances · Mar 19, 2025Peer-reviewedCell Biology