Dynamic S-acylation controls CMG2 maturation, extracellular matrix regulation, and anthrax toxin entry
Laurence Abrami, Sanja Blašković, Octave Joliot, Vincent Mercier, Béatrice Kunz, Francisco Sarmento Mesquita, F. Gisou van der Goot
This study identifies S-acylation-deacylation cycles as regulators of CMG2 biogenesis and function, showing APT2 inhibition can block anthrax toxin entry and Collagen VI degradation.
bioRxiv · Jan 7, 2026 · PreprintCell Biology