F. Gisou van der Goot

The luminal and cytosolic domains of CLIMP-63 cooperate to set ER sheet width

This study shows that CLIMP-63's luminal domain forms flexible trimers and its cytosolic tail mediates clustering, together determining ER sheet width.

Molecular Regulation and Physiological Role of 1 GOLPH3-mediated Golgi retention

This study investigates the role of GOLPH3 in Golgi retention and trafficking, showing its regulation by S-acylation and its impact on glycosylation and development.

An overexpression platform reveals the functional diversity of human KRAB-Zinc Finger Proteins in maintaining cellular homeostasis

The paper identifies functional roles of human KZFPs through overexpression screening and integrative analysis, revealing diverse mechanisms in cellular homeostasis.

Dynamic S-acylation controls CMG2 maturation, extracellular matrix regulation, and anthrax toxin entry

This study identifies S-acylation-deacylation cycles as regulators of CMG2 biogenesis and function, showing APT2 inhibition can block anthrax toxin entry and Collagen VI degradation.

Identification of a Lipid Oxygen Radical Defense pathway and its epigenetic control

The paper identifies the Lipid Oxygen Radical Defense (LORD) pathway and shows it is epigenetically controlled, affecting oxidative stress and ferroptosis.

Antxr2-mediated fine-tuning of Collagen VI ensures skeletal muscle function

This study shows that ANTXR2 regulates COL6 turnover in skeletal muscle, and its deficiency leads to ECM stiffening and muscle dysfunction.

Anthrax toxin receptor 2 is the Receptor for Clostridium perfringens NetF: Structural Insights into Toxin Binding and Pore Formation

This study identifies ANTXR2 as the receptor for C. perfringens NetF toxin, revealing structural insights into its binding mechanism and pore formation.

Intestinal stem cell renewal controlled by capillary morphogenesis gene 2 following injury

This study shows that CMG2 is essential for intestinal stem cell renewal after injury, as its loss impairs stem cell regeneration and Wnt signaling in mice.

A toxic palmitoylation on Cdc42 drives a severe autoinflammatory syndrome

The paper identifies a mutation in Cdc42 that causes a severe autoinflammatory syndrome by trapping the protein in the Golgi and disrupting its membrane interaction.

The architecture of the endoplasmic reticulum is regulated by the reversible lipid modification of the shaping protein CLIMP-63

This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.