Francisco Sarmento Mesquita

This study investigates the role of GOLPH3 in Golgi retention and trafficking, showing its regulation by S-acylation and its impact on glycosylation and development.

The paper identifies a protective pathway where LLO-induced Src activation phosphorylates NMHC2A, enabling cytoskeletal reorganization and PM damage response, conserved in C. elegans.

This study identifies S-acylation-deacylation cycles as regulators of CMG2 biogenesis and function, showing APT2 inhibition can block anthrax toxin entry and Collagen VI degradation.

The paper identifies the Lipid Oxygen Radical Defense (LORD) pathway and shows it is epigenetically controlled, affecting oxidative stress and ferroptosis.