Richard D. Leapman

Evolution of a fuzzy ribonucleoprotein complex in viral assembly

The paper investigates how mutations in SARS-CoV-2 N protein affect RNP formation and stability, finding convergent evolution and enhanced RNP assembly in Omicron variants.

Study on Liver Sinusoidal Endothelial Cell Fenestrations Based on Cellular Omics-Structure Integration Technology and Its Application in Metabolic Diseases

This study introduces a new COSI technology platform that integrates single-cell transcriptomics with super-resolution imaging to analyze liver sinusoidal endothelial cell fenestrations and their association with metabolic diseases.

U-Net Ensembles for Segmentation of High-Density Cell Populations and Organelles

The paper develops a U-Net ensemble method for segmenting cells and organelles in 3D vEM data, achieving state-of-the-art results on CREMI neuron data and murine thrombus platelets.

Biological volume EM with focused Ga ion beam depends on formation of radiation-resistant Ga-rich layer at block face

This study investigates how FIB-SEM achieves high resolution in biological volume EM by forming a radiation-resistant Ga-rich layer at the block face, preventing specimen collapse and damage.

Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation

The paper maps platelet activation states in thrombi to show how their spatial distribution changes during hemostasis, finding distinct clustering of highly activated platelets at later stages.

Circadian modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1

The paper shows circadian rhythms in hippocampal CA1 neurons and astrocytes affect synaptic plasticity through changes in NMDA receptor expression and astrocytic proximity to synapses, altering glutamate clearance and cognitive processing.