NeuroscienceJournal of NeurosciencePeer-reviewed
Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration
Ying Jiang, Kuldeep Sachdeva, Chris N. Goulbourne…·Ralph A. Nixon
This study shows that overexpressing APPL1 in neurons causes AD-like endosomal and synaptic dysfunction, cholinergic neurodegeneration, and memory deficits in mice.
2 citations