Author

Kuldeep Sachdeva

Nathan Kline Institute for Psychiatric ResearchORCID 0000-0002-7355-2805Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Anna PensalfiniiD· 1 shared Balapal S. BasavarajappaiD· 1 shared Chris N. GoulbourneiD· 1 shared Cynthia Bleiwas· 1 shared James Peddy· 1 shared John F. SmileyiD· 1 shared Lauren S. WhyteiD· 1 shared Martin J. BergiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Anna PensalfiniORCID

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1 paper

Recent·Most cited

Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration

Ying Jiang, Kuldeep Sachdeva, Chris N. Goulbourne, Martin J. Berg, James Peddy, Philip H. Stavrides, Anna Pensalfini, Monika Pawlik, Sandeep Malampati, Lauren S. Whyte, Balapal S. Basavarajappa, Shivakumar Subbanna, Cynthia Bleiwas, John F. Smiley, Paul M. Mathews, Ralph A. Nixon

This study shows that overexpressing APPL1 in neurons causes AD-like endosomal and synaptic dysfunction, cholinergic neurodegeneration, and memory deficits in mice.

Journal of Neuroscience · Jun 13, 2025Peer-reviewedNeuroscience