Author

James Peddy

Nathan Kline Institute for Psychiatric Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Chris N. GoulbourneiD· 2 shared Philip H. StavridesiD· 2 shared Ralph A. NixoniD· 2 shared Anna PensalfiniiD· 1 shared Balapal S. BasavarajappaiD· 1 shared Chunfeng Huo· 1 shared Cynthia Bleiwas· 1 shared Deanna M. MarchioniniiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Chris N. GoulbourneORCID

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2 papers

Recent·Most cited

Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration

Ying Jiang, Kuldeep Sachdeva, Chris N. Goulbourne, Martin J. Berg, James Peddy, Philip H. Stavrides, Anna Pensalfini, Monika Pawlik, Sandeep Malampati, Lauren S. Whyte, Balapal S. Basavarajappa, Shivakumar Subbanna, Cynthia Bleiwas, John F. Smiley, Paul M. Mathews, Ralph A. Nixon

This study shows that overexpressing APPL1 in neurons causes AD-like endosomal and synaptic dysfunction, cholinergic neurodegeneration, and memory deficits in mice.

Journal of Neuroscience · Jun 13, 2025Peer-reviewedNeuroscience

mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

Philip H. Stavrides, Chris N. Goulbourne, James Peddy, Chunfeng Huo, Mala V. Rao, Vinod K. Khetarpal, Deanna M. Marchionini, Ralph A. Nixon, Dun‐Sheng Yang

This study shows that mTOR inhibition in HD model mice improves autophagy and reduces mutant huntingtin accumulation.

eLife · Jan 28, 2025Peer-reviewedPathology