Chris N. Goulbourne

This study uses mouse models with tau mutations to show two distinct pathogenic mechanisms in tauopathies, with different progression patterns and responses to amyloid.

This study shows that overexpressing APPL1 in neurons causes AD-like endosomal and synaptic dysfunction, cholinergic neurodegeneration, and memory deficits in mice.

This study shows that mTOR inhibition in HD model mice improves autophagy and reduces mutant huntingtin accumulation.