5-ethynyluridine perturbs nuclear RNA metabolism to promote the nuclear accumulation of TDP-43 and other RNA binding proteins
Lindsey R. Hayes, Benjamin L. Zaepfel, Lauren Duan, Anne C Starner, Mason D. Bartels, Rebekah L. Rothacher, Sophie Martin, Rachel L. French, Zhe Zhang, Irika R. Sinha, Jonathan P. Ling, Shuying Sun, Yuna M. Ayala, Jeff M. Coller, Eric L. Van Nostrand, , Petr Kaláb
This study shows that 5-ethynyluridine (5EU) causes nuclear accumulation of TDP-43 and other RNA-binding proteins by altering RNA metabolism and splicing.
bioRxiv · Apr 2, 2025 · PreprintCell Biology