Jeff M. Coller

This study investigates the in vitro interaction between eIF4E and Dcp2, showing that eIF4E does not interfere with Dcp2's decapping activity and may even enhance its RNA binding affinity.

This study shows that 5-ethynyluridine (5EU) causes nuclear accumulation of TDP-43 and other RNA-binding proteins by altering RNA metabolism and splicing.

The paper shows the Ccr4-Not complex interacts with the ribosome's E-site when codon optimality is low, linking translation efficiency to mRNA stability.

The paper shows that codon usage and amino acid identity significantly influence mRNA stability in humans, affecting protein abundance through translational elongation rates.

The paper shows that faster translation elongation on optimal codons increases mRNA stability in yeast, with A-site tRNA decoding being the key factor driving mRNA decay.

The paper introduces END-seq to measure poly(A) tail lengths transcriptome-wide in yeast and shows Ccr4 and Pop2 differentially regulate these tails.