Author

Lauren Duan

Johns Hopkins UniversityORCID 0000-0002-0715-0824Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Cell Biology· 1 Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

William Rowland GoodyeriD· 2 shared A.D. Choudhury· 1 shared Ahmad SalehiiD· 1 shared Alan Gi-Lun ChengiD· 1 shared Ali Reza Rais Sadati· 1 shared Amber Casillas· 1 shared Andres Gottfried‐BlackmoreiD· 1 shared Angela Oliveira PiscoiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioinformatics

William Rowland GoodyerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Activity-gated exocytosis drives myelin remodeling required for adult learning

Mable Lam, Oleh Dehtiarov, Anna C. Geraghty, Belgin Yalçın, Lauren Duan, Manasi Iyer, Kristen H. Schuster, Michelle Monje, Ethan G. Hughes, J. Bradley Zuchero

This study identifies activity-dependent exocytosis in mature oligodendrocytes as a mechanism driving myelin remodeling necessary for adult learning.

bioRxiv · Oct 21, 2026 · PreprintNeuroscience

Benchmarking Cell Type and Gene Set Annotation by Large Language Models with AnnDictionary

George Crowley, Robert C. Jones, Mark A. Krasnow, Angela Oliveira Pisco, Julia Salzman, Nir Yosef, Siyu He, Madhav Mantri, Jessie Aguirre, Ron Garner, Sal Guerrero, William Harper, Resham Irfan, Sophia Mahfouz, Ravi Ponnusamy, , David Seong

The paper benchmarks large language models for cell-type and gene set annotation using AnnDictionary, finding high accuracy in cell-type annotation and strong functional gene set recovery.

Nature Communications · Oct 28, 2025Peer-reviewedBioinformatics

5-ethynyluridine perturbs nuclear RNA metabolism to promote the nuclear accumulation of TDP-43 and other RNA binding proteins

Lindsey R. Hayes, Benjamin L. Zaepfel, Lauren Duan, Anne C Starner, Mason D. Bartels, Rebekah L. Rothacher, Sophie Martin, Rachel L. French, Zhe Zhang, Irika R. Sinha, Jonathan P. Ling, Shuying Sun, Yuna M. Ayala, Jeff M. Coller, Eric L. Van Nostrand, , Petr Kaláb

This study shows that 5-ethynyluridine (5EU) causes nuclear accumulation of TDP-43 and other RNA-binding proteins by altering RNA metabolism and splicing.

bioRxiv · Apr 2, 2025 · PreprintCell Biology

Interpreting variants associated with congenital heart disease with a regulatory map of the human fetal heart

X. Rosa Ma, Stephanie D. Conley, Maggie S. Chen, Michael Kosicki, Yifan Lu, Danila Bredikhin, Ran Cui, Maya U. Sheth, Wei‐Lin Qiu, Dulguun Amgalan, Sijie Chen, Robin M. Perelli, Neil Slaven, Michael T. Montgomery, Sarah Fan Xia, , J Engreitz

This study creates a gene regulation map of the human fetal heart to interpret genetic variants associated with congenital heart disease and cardiac traits, identifying valvular interstitial cells as key regulators.

medRxiv · Nov 20, 2024 · PreprintGenetic & Genomic Medicine