Janakiram Seshu

This study evaluates non-infectious mutant strains of Borrelia burgdorferi and their lipoproteins as biologics to prevent Lyme disease transmission by reducing bacterial acquisition in ticks.

The paper identifies a tick saliva protein that specifically binds to Borrelia burgdorferi lipids, suggesting a potential role in pathogen recognition.

This study evaluates an oral vaccine formulation of purified Borrelial Lipoproteins (PBL) with adjuvants to reduce Lyme disease transmission from reservoir hosts to ticks.

This study identifies DUSP1 as a regulator of inflammatory and mitochondrial responses in macrophages exposed to Borrelia burgdorferi lipoproteins, with implications for therapeutic targeting.