Kari Salokas

This paper describes a method to obtain brain tissue for omic analyses using SEEG electrodes, showing concordant transcriptomic and proteomic findings across different epileptic zones.

This study optimizes VSV-G-pseudotyped lentiviral transduction of NK cells by improving activation, construct design, and enhancer use, achieving high efficiency without compromising cell function.

This study identifies POLE2 as a general NPF-motif receptor, revealing its role in recruiting proteins involved in replication, DNA repair, and transcription through SLiM-mediated interactions.

The paper describes a FINCA mouse model with mild hyperactivity and altered immune response, identifying Rho GTPase signaling as a key pathway affected by the p.Asp148Tyr variant in NHLRC2.

This study shows that resistance training induces reversible and retained proteomic changes in human skeletal muscle, suggesting a proteomic memory of muscle growth.

The paper maps the interactome and substrates of human receptor tyrosine kinases using AP-MS, BioID, and kinase assays, revealing interactions and functions of both well-known and understudied RTKs.

The paper analyzes oncogenic gene fusions in cancer, finding that 30% of detected fusions produce functional proteins, primarily involving kinases and transcription factors, which deregulate cellular signaling.

The paper develops an integrated approach combining AP-MS and BioID to map protein interactions and molecular contexts across the human proteome.