Author

Helka Göös

Finnish Red CrossORCID 0000-0002-6175-4872Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Emmi JärveläiD· 4 shared Diana SchenkweiniD· 3 shared Lotta Andersson· 3 shared Matti Korhonen· 3 shared Mira SaariiD· 3 shared Seppo Ylä-HerttualaiD· 3 shared Erja KerkeläiD· 2 shared Farhana JahaniD· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Emmi JärveläORCID

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4 papers

Recent·Most cited

Biomimetic virus-like mesoporous silica nanoparticles activate NK cells indirectly via monocyte crosstalk

Minna Sivonen, Silja Saarela, Jiajia Wang, Mira Saari, Emmi Järvelä, Lotta Andersson, Enkhzaya Batnasan, Leena Latonen, Helka Göös, Vesa‐Pekka Lehto, Wujun Xu

This study shows that biomimetic virus-like mesoporous silica nanoparticles activate NK cells through monocyte crosstalk by optimizing spike length, surface functionalization, and cell membrane coating.

Nano Letters · Aug 27, 2026Peer-reviewedImmunology

Efficient NK cell transduction with VSV-G-pseudotyped lentiviral vectors

Emmi Järvelä, Jan Koski, Farhana Jahan, Antti Tuhkala, Mira Saari, Manar Elmadani, Kari Salokas, Laurens Veltman, Lotta Andersson, Erja Kerkelä, Hekim Can, Marie C. Nyman, Seppo Ylä-Herttuala, Markku T Varjosalo, Diana Schenkwein, , Helka Göös

This study optimizes VSV-G-pseudotyped lentiviral transduction of NK cells by improving activation, construct design, and enhancer use, achieving high efficiency without compromising cell function.

Molecular Therapy Advances · May 5, 2026Peer-reviewedImmunology

Feeder cell - the key component in producing scalable and fit NK cells for therapeutic use

Mira Saari, Farhana Jahan, Lotta Andersson, Anna Syreeni, Pirjo Vehmaan-Kreula, Jan Koski, Emmi Järvelä, Erja Kerkelä, Henrik Paavilainen, Diana Schenkwein, Seppo Ylä-Herttuala, Kim K. Vettenranta, Helka Göös, Matti Korhonen

This study evaluates engineered K562 feeder cells for enhancing NK cell expansion and function in ex vivo cultures, showing up to 500-fold higher yields compared to feeder-free systems.

bioRxiv · Apr 23, 2026 · PreprintImmunology

Multimodal immunopharmacologic screens identify drugs rewiring the cancer-immune interface

Jonas Bouhlal, Emmi Jokinen, Petra Johanna Nygren, Diogo Dias, Aleksandr Ianevski, Jay Klievink, Hanna Lähteenmäki, Salomé Decombis, Hanna Duàn, Emmi Järvelä, Emma Saarinen, Anna Näätänen, Konstantin Matjusinski, Tiina Kasanen, Tiina Hannunen, , Satu M. Mustjoki

The paper identifies drugs that rewiring the cancer-immune interface by enhancing NK cell function and tumor susceptibility through multimodal screening approaches.

bioRxiv · Apr 17, 2026 · PreprintCancer Biology