Antti Tuhkala

This paper describes a method to obtain brain tissue for omic analyses using SEEG electrodes, showing concordant transcriptomic and proteomic findings across different epileptic zones.

This study optimizes VSV-G-pseudotyped lentiviral transduction of NK cells by improving activation, construct design, and enhancer use, achieving high efficiency without compromising cell function.

This study identifies POLE2 as a general NPF-motif receptor, revealing its role in recruiting proteins involved in replication, DNA repair, and transcription through SLiM-mediated interactions.

This study shows ISG15 modulates Clade Ib and II MPXV infection differently in MEF cells, with clade-specific effects on viral replication and immune evasion.

This paper presents a T cell gene correction pipeline using CRISPR/Cas9 and HDR to correct monogenic mutations in IEI models, achieving up to 80% bi-allelic editing with no detectable off-target effects.