Author

Michelle Anne Farrar

UNSW SydneyORCID 0000-0002-4472-0902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Research Focus:variant effect prediction· 1 Organism:zebrafish· 1

Frequent Co-Authors

Afsaneh Taghipour‐SheshdehiD· 1 shared Ann-Maree Huang· 1 shared Austin R. Nelson· 1 shared Brett William StringeriD· 1 shared Brunhilde WirthiD· 1 shared Grant J. LoganiD· 1 shared Heike KölbeliD· 1 shared Ian E. AlexanderiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Afsaneh Taghipour‐SheshdehORCID

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2 papers

Recent·Most cited

NeuroscienceEMBO Molecular MedicinePeer-reviewedDec 15, 2025

Clinical relevance of zebrafish for gene variants testing. Proof-of-principle with SMN1/SMA.

Brett William Stringer, Yougang Zhang, Afsaneh Taghipour‐Sheshdeh…·Jean Giacomotto

The paper uses a zebrafish model to test the pathogenicity of SMN1 variants in SMA patients, showing that two variants were non-pathogenic and avoiding costly treatments.

4 citations

zebrafishexperimental assay

ImmunologyNature CommunicationsPeer-reviewedApr 19, 2025

Structural characterization of antibody-responses from Zolgensma treatment provides the blueprint for the engineering of an AAV capsid suitable for redosing

Mario Mietzsch, Jane Hsi, Austin R. Nelson…·ROBERT V. McKENNA

This study uses cryo-EM to analyze antibodies against AAV9 vectors, identifying residues that enable capsid engineering to avoid neutralization and allow redosing.

15 citationstop 2%

humancryo-EM