Jean Giacomotto

The paper uses a zebrafish model to test the pathogenicity of SMN1 variants in SMA patients, showing that two variants were non-pathogenic and avoiding costly treatments.

This study generates zebrafish neurexin gene knockouts and identifies paralog-specific behavioral changes linked to anxiety, social behavior, and aggression, mirroring human psychiatric disorders.

The paper develops an inducible miRNA-delivery system in zebrafish to enable spatiotemporal gene silencing and traceable knockdowns, improving upon existing methods for studying microRNA biology and genetic disorders.

The paper uses calcium imaging to study brain-wide visual habituation networks in zebrafish, finding altered network dynamics in fmr1 mutants linked to slower habituation.

The paper describes a method to generate stable large genomic deletions in zebrafish using CRISPR/Cas9, demonstrating its effectiveness for various deletion sizes and gene families.