Changhan He

The paper introduces Incytr, a method for discovering cell signaling pathways from multi-omics data, demonstrating its application in disease contexts and showing its utility for drug discovery and understanding cell communication.

exFINDER identifies external signals received by cells from their environment using single-cell transcriptomics data, revealing signaling networks and biological activities.

The paper reports oscillatory behavior in a self-activation gene circuit induced by nutrient-modulating growth feedback and validates it with a mathematical model.

This paper designs a synthetic gene circuit to study reaction-diffusion patterning in bacteria, showing how gene network topology influences stripe formation.