Author

Ed Hurt

Heidelberg UniversityORCID 0000-0002-4535-8255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:fungi (other)· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Matthias ThomsiD· 3 shared Roland BeckmanniD· 3 shared Timo DenkiD· 3 shared Anthony K. HenrasiD· 2 shared Hussein HamzeiD· 2 shared Alina S. ThieleniD· 1 shared Amit SinghiD· 1 shared Anna ForstneriD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

Matthias ThomsORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

RNA helicase Drs1 gates 25S rRNA domain III incorporation during early nucleolar pre-60S maturation

Matthias Thoms, Sanem Ayaz-Kök, Kohei Abe, Hussein Hamze, Alina S. Thielen, Timo Denk, Benjamin Albert, Nika Mikulič Vernik, Leona Chiţoiu, Elise Laurent, Ed Hurt, Anthony K. Henras, Roland Beckmann, Valentin Mitterer

This study identifies Drs1 as a key RNA helicase that facilitates the incorporation of 25S rRNA domain III during early pre-60S ribosome maturation by interacting with Erb1 and remodeling pre-rRNA.

bioRxiv · Sep 9, 2026 · PreprintBiochemistry

A bifunctional H/ACA snoRNP mediates both pseudouridylation and rRNA scaffolding during ribosome assembly

Jutta Hafner, Matthias Thoms, Hussein Hamze, Anna Forstner, Ismaël Alidou-D’Anjou, Hafiza Hebbachi, М. В. Калинина, Annika Hausharter, Sébastien Favre, Simon Lebaron, Sherif Ismail, Timo Denk, Katharina Schlick, Thomas Fröhlich, Priya Bhutada, , Brigitte Pertschy

This study identifies snR37 as a bifunctional H/ACA snoRNP that both pseudouridylates rRNA and scaffolds ribosome assembly during pre-60S intermediate formation.

bioRxiv · Apr 1, 2026 · PreprintBiochemistry

H/ACA snoRNP guides ribosomal RNA subdomain folding in a satellite particle before joining the core 90S pre-ribosome

Paulina Luisa Fischer, Matthias Thoms, Benjamin Lau, Timo Denk, Maria Kuvshinova, Otto Berninghausen, Dirk Flemming, Ed Hurt, Roland Beckmann

The paper shows that the H/ACA snoRNP snR30 forms a satellite particle to guide 18S rRNA subdomain folding before integrating into the 90S pre-ribosome, enhancing ribosome assembly accuracy.

Nature Communications · May 21, 2025Peer-reviewedBiochemistry

Global Transcriptome Characterization and Assembly of Thermophilic Ascomycete Chaetomium thermophilum

Amit Singh, Géza Schermann, Sven Reislöhner, Nikola Kellner, Ed Hurt, Michael Brunner

This study annotates the full-length transcripts of Chaetomium thermophilum using deep RNA sequencing, identifying novel genes and improving existing annotations.

Genes · Sep 29, 2021Peer-reviewedBioinformatics