Author

David C. Butler

Neural Stem Cell Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Steven Lotz· 3 shared Celeste M M. KarchiD· 2 shared Lianna D’Brant· 2 shared Michael J. MilleriD· 2 shared Natasha Rugenstein· 2 shared Sally TempleiD· 2 shared Shona Joy· 2 shared Susan K. Goderie· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Steven Lotz

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Large-scale single-molecule analysis of tau proteoforms

James H. Joly, Vivekananda Budamagunta, Zhengjian Zhang, Brittany Nortman, Maryam Jouzi, Rajat Bhatnagar, Jarrett D. Egertson, Michael E. Flaster, Rob Grothe, Sanjib K Guha, Kota Kaneshige, Kevin McVey, Nicholas Nelson, Rukshan T. Perera, Steven J. Tan, , Cara Li

This paper introduces IMaP, a method to analyze tau proteoforms at the single-molecule level, revealing ordered phosphorylation patterns and disease-specific modifications.

Nature Methods · Sep 1, 2026Peer-reviewedBiochemistry

HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer's Disease

Emmanuel C. Ijezie, Michael J. Miller, Céline Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D’Brant, Natasha Rugenstein, Adam Tully Waickman, Eain A. Murphy, David C. Butler

This study shows HSV-1 infection alters MAPT splicing, increases 4R-Tau protein and hyperphosphorylation, and promotes Tau pathology in neural models.

Brain Pathology · Mar 26, 2025Peer-reviewedMicrobiology

Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of MAPT Mutation iPSC-derived Neurons

Lianna D’Brant, Natasha Rugenstein, Su Kyoung Na, Michael J. Miller, Timothy F. Czajka, Nicole Trudeau, Emily M Fitz, Lindsay Tomaszek, Elizabeth S. Fisher, Ethan Mash, Shona Joy, Steven Lotz, Susan M. Borden, Katherine Stevens, Susan K. Goderie, , David C. Butler

The paper develops fully human bifunctional anti-tau intrabodies that reduce intracellular tau and improve neuronal survival in disease-associated mutations.

bioRxiv · May 28, 2024 · PreprintNeuroscience

Integrated Manufacturing Platform for Cortical Organoids Reveals Early Phosphatase and Prefoldin Dysregulation in MAPT V337M Neurons

Taylor B. Bertucci, Kathryn R. Bowles, Steven Lotz, Shiraz Bheda, Le Qi, Farhad Farjood, Katherine Whitton, Susan K. Goderie, Susan M. Borden, Amelia Rossi, Kate Tubbesing, Chiara Pedicone, Laura Maria Oja, Keith Lane, Ryan Lotz, , Sally Temple

The paper develops a scalable cortical organoid platform with quality control metrics and identifies early dysregulation of phosphatase and prefoldin genes in FTD-tau neurons.

bioRxiv · Jul 11, 2023 · PreprintNeuroscience